Research Paper Volume 15, Issue 19 pp 10524—10539
Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway
Figure 6. PRXT inhibited TGF-β1-induced activation of lung fibroblasts in a concentration-dependent manner. (A) Cell viability in primary lung fibroblasts treated with different concentrations of PRTX (n=5). (B) Cell viability in TGF-β1-induced primary lung fibroblasts treated with different concentrations of PRTX (n=5). (C, D) Relative mRNA expression levels of α-SMA and Collagen I in primary lung fibroblasts (n=5). *P < 0.05 vs. the PBS group, #P < 0.05 vs. the TGF-β1 group. PRTX, Paroxetine.