CDKN2A was a cuproptosis-related gene in regulating chemotherapy resistance by the MAGE-A family in breast cancer: based on artificial intelligence (AI)-constructed pan-cancer risk model

Hong Wan; Xiaowei Yang; Guopeng Sang; Zhifan Ruan; Zichen Ling; Mingzhao Zhang; Chang Liu; Xiangyang Hu; Tao Guo; Juntong He; Defeng Liu; Jing Pei

doi:doi:10.18632/aging.205125

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Research Paper Volume 15, Issue 20 pp 11244—11267

CDKN2A was a cuproptosis-related gene in regulating chemotherapy resistance by the MAGE-A family in breast cancer: based on artificial intelligence (AI)-constructed pan-cancer risk model

Figure 14. Inhibition of CDKN2A weakens tumor metastasis and immune escape in breast cancer. (A) Wound healing assay and (B) transwell assay show down-regulation of CDKN2A or MEGEA4 inhibits the cell migration ability. (C) WB detection shows down-regulation of CDKN2A decreases the expression level of ZO1, MMP9, VIM, Twist1, Snail1, and Zeb1, while E-cad is up-regulated. (D) Down-regulation of CDKN2A decreases the expression of MAGEA, Cas3, c-cas4, p-STAT3 and PD-L1, while c-cas3 is up-regulated.