Research Paper Volume 15, Issue 24 pp 14651—14665

The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans

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Figure 1. Acein regulates aging by influencing dopamine level. (A) Survival curve of 10 nM, 100 nM and 1000 nM Acein groups. (B) Survival curve of 5 nM, 10 nM and 20 nM Acein groups. (C) Dopamine content in C.elegans after 48 h of 10 nM Acein treatment. (D) Change of dopamine level in C. elegans with age after treatment with 10 nM Acein. (E) C.elegans body length after treatment with 10 nM Acein. (F) C. elegans body width after treatment with 10 nM Acein. (G) C.elegans progeny number after treatment with 10 nM Acein. (H) Body bending detection of C.elegans after treatment with 10 nM Acein. (I) Head swing detection of C.elegans after treatment with 10 nM Acein. (J) Pharyngeal pumping detection of C.elegans. Compared with the vehicle group. nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001.