Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Yingjing Zhao; Yuxue Mu; Yujia Zou; Zhijian He; Tianxing Lu; Xinhui Wang; Weihang Li; Bo Gao

doi:doi:10.18632/aging.205289

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Research Paper Volume 15, Issue 24 pp 14764—14790

Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Figure 4. (A) Venn diagram suggesting 33 genes were commonly expressed genes in three parts. (B) PPI construction of the commonly expressed genes to identify the most significant hub genes. (C) Featureplot visualization about the hub genes between degeneration and non-degeneration group at single-cell resolution. (D) Relative mRNA expression levels of the four hub genes in the control and degeneration groups.