Research Paper Volume 15, Issue 24 pp 14864—14888
Exosomal hsa-miR-151a-3p and hsa-miR-877-5p are potential novel biomarkers for predicting bone metastasis in lung cancer
Figure 4. PPI network, modular analysis, and miRNA-mRNA network construction. The PPI network of 101 target genes of the 29 exo-miRNAs was analyzed using the STRING database (A) and Cytoscape software (B). (C) The key module was identified from the PPI network using the MCODE plug-in of Cytoscape. (D) The hub genes (degree: top 10) identified by the Cytohubba plug-in. (E) miRNA-hub gene network. In the miRNA-hub mRNA network, the pink ellipses represented hub genes, and the green triangles represented key miRNAs.