hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Yu Wang; Zhenlin Li; Jun He; Wenxiang Chen; Yiming Li; Xiangmei Chen; Junjie Liang; Qiangfeng Yu; Jianyin Zhou

doi:doi:10.18632/aging.205317

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Research Paper Volume 15, Issue 24 pp 14915—14929

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Figure 8. miR-1303 attenuated CADM2-mediated inhibition in migration and invasion of LC cells. HepG2 and Huh7 cells were transfected with miR-1303 mimics and circ_0002980 overexpression plasmids. (A) The ability of cell migration was viewed via Transwell assay in each group. Magnification, 200×. (B) Cell invasion was tested through Transwell in each group. Magnification, 200×. (C) Western blotting analysis of EMT-related proteins. (D) Quantitative analysis of proteins. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001.