Research Paper Volume 15, Issue 24 pp 14553—14573

Systemic changes induced by autologous stem cell ovarian transplant in plasma proteome of women with impaired ovarian reserves

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Figure 3. Plasma proteomic changes three months after stem cell mobilization/injection in patients with premature ovarian insufficiency. Heatmap depicting the hierarchical clustering of the 24 differentially expressed proteins (DEPs)between PRE and POST samples in the mobilization arm (A), and dot plot showing the corresponding top 30 significantly enriched (FDR < 0.05) GO biological processes (B). (C) Heatmap depicting the hierarchical clustering of the 11 DEPs between PRE and POST samples in the ASCOT arm. (D) Venn diagram highlighting the shared DEPs between POST samples of both study arms. The heatmaps are color coded according to protein expression determined by SWATH analysis, where yellow and turquoise indicate an increase or decrease in expression, respectively.