Research Paper Volume 16, Issue 4 pp 3200—3230

Transcriptomic and network analysis identifies shared and unique pathways and immune changes across fibrotic interstitial lung diseases

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Figure 5. Network and pathway analyses of common DEGs in the lung tissues of fHP patients. Network and pathways were performed on the dataset from fHP patients compared to non-demented controls to identify unique dysregulated pathways in the lung tissues of fHP. (A, B) Network analysis of up-regulated genes and down-regulated genes. Most significant hub genes, according to degree and betweenness centrality, with the highest number of connections, are enclosed in ovals. (C, D) Function enrichment analysis of the up-regulated and down-regulated common DEGs, where the horizontal axis represents the proportion of DEGs under the functional terms. Top 5 pathways with most significant P-value were shown and ordered by gene ratio.