Research Paper Volume 15, Issue 19 pp 10213—10236

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis

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Figure 7. ICT suppresses OVX-induced bone loss. Twelve-week-old female mice were randomly arranged into three groups, that is Sham (Sham + Vehicle), OVX (OVX + Vehicle), and ICT (OVX + ICT). After being subjected to sham or OVX surgery, mice were treated with vehicle or ICT for 6 weeks. (A) Representative 3D reconstruction micro-CT images of the trabecular bone from each group. (B) The measurement data of BV/TV, Tb.Th, Tb.N, and Tb.Sp from each group through built-in software of CT system. All data were presented as mean ± SD, n = 6. Abbreviation: ns: not statistical significance. *P < 0.05; **P < 0.01; ****P < 0.0001.