Research Paper Volume 15, Issue 20 pp 11152—11161
The novel GLP-1/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK/ACC signaling pathway
Figure 5. Inactivation of AMPK/ACC signaling pathway by Com-C significantly reversed the influence of DA3-CH on pancreatic injury. (A) HE staining was performed to investigate the influence of DA3-CH and Com-C on pancreatic tissue injury in vivo; (B) Tunel staining was performed to investigate the influence of DA3-CH and Com-C on apoptosis level in vivo; (C) The staining intensity was analyzed; (D) IHC staining was performed to investigate the influence of DA3-CH and Com-C on Bax expression in vivo; (E) The staining intensity was analyzed; * means p <0.05. n=3 for each group.