Research Paper Volume 15, Issue 20 pp 11313—11330

Figure 5. (A) Correlation of immune infiltration with NF-κB-related genes. The area of the circle represents ABS (correlation), and the color shows the p-value. (B–D) Scatterplots show the specific relationship between the three immune cells (Treg, neutrophils and CCR) and NF-κB score; they are all positively correlated. (E) Expression of NF-κB-related genes between the two samples. Red and blue represent up- and downregulation, respectively, N (green) is the normal sample, and T (red) represents the tumor sample (*: p<0.05, **: p<0.01, ***: p<0.001). (F) Forest plot showing hazard ratio analysis and p-values for 95% confidence intervals for 21 NF-κB-related genes. (G, H) LASSO coefficient spectra of NF-κB-related genes in patients with KIRC. LASSO Cox regression analysis was used to screen out the 11 genes. (I) Build 101 predictive models and calculate the C-index for each model on all validation datasets.