Research Paper Volume 15, Issue 23 pp 13738—13752

Involvement of RFC3 in tamoxifen resistance in ER-positive breast cancer through the cell cycle

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Figure 2. MCF-7-like organ transcriptome sequencing analysis functional analysis of GO and KEGG. (A) GO functional enrichment analyses of biological processes involved in breast cancer cellular process alterations in multiple ways, with the cell cycle approach in biological processes being the most significant. (B) The KEGG enrichment pathway is involved in multiple pathways in extracellular matrix-associated cellular process alterations, most notably through the cell cycle approach. (C) The RFC3, RFC5 and PCNA genes of the KEGG pathway are involved in the cell cycle through deoxyribonucleic acid replication.