Research Paper Volume 15, Issue 23 pp 14172—14191

Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer’s disease-like neuropathology and cognitive deficits

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Figure 5. GP improves learning and memory impairment in STP-treated rats. (A) Study design timeline performed in the study. (B) The total distance was analyzed in the open-field test. (CD) Escape latency in 4 days was analyzed in the Barnes maze test. (E) Escape latency on test day 5 was analyzed in the Barnes maze test. (F, G) The novel object recognition (NOR) test showed the measured recognition index of the new object within 24 hours. Data represent mean ± SEM, p-value significance is calculated from one-way ANOVA. *p < 0.05, **p < 0.01, ***P < 0.001 and ****P < 0.0001, Abbreviation: NS: no significance. n represents the number of rats in each group. For (B), Control n = 11, STP n = 11, STP+GP200 n = 11, STP+GP400 n = 10. For (D, E), Control n = 9, STP n = 14, STP+GP200 n = 10, STP+GP400 n = 11. For (B), Control n = 9, STP n = 8, STP+GP200 n = 8, STP+GP400 n = 7.