Research Paper Volume 15, Issue 24 pp 15050—15063

Figure 5. ENO1, NDGR1 and NPM1 expression in HCC tissues. (A) PPI network identifies ENO1 as hub gene of signature. (B, C) The expression of ENO1 gene in paracellular tissues and hepatocellular carcinoma tissues. (D) The protein expression of ENO1, NDGR1, NPM1, TXNRD1 and IL-33 in hepatocellular carcinoma tissues and paracellular tissues (n= 10 per group). Samples were stained with H&E staining to observe the structure of paracellular tissues and hepatocellular carcinoma tissues (n= 10 per group). Patients’ essential characteristics were shown in Supplementary Table 4. Normal (*): paracellular tissues; Tumor (*): hepatocellular carcinoma tissues, EDMONDSON Classification: II; Microvascular tumor thrombus: MVI grade 0; Tumor (**): hepatocellular carcinoma tissues, EDMONDSON Classification: III-IV; Microvascular tumor thrombus: MVI grade 1.