Sesamin-mediated high expression of <i>BECN2</i> ameliorates cartilage endplate degeneration by reducing autophagy and inflammation

Baining Zhang; Zhiwei He; Jialin Guo; Feng Li; Zhi Huang; Wenkai Zheng; Wenhua Xing; Manglai Li; Yong Zhu; Xuejun Yang

doi:doi:10.18632/aging.205386

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Research Paper Volume 16, Issue 2 pp 1145—1160

Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation

Figure 1. Transcriptome analysis molecular mechanism of Sesamin on LPS-induced ATDC5 degeneration. (A) volcano map of mRNA expression profiles. (B) The top50 of differentially expressed genes (DGEs). (C) The top 10 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of DEGs. (D) The top 10 enriched Gene Ontology (GO) pathway of the DEGs sorted by significance in biological process (BP), cellular component (CC) and molecular function (MF).