Research Paper Volume 15, Issue 24 pp 15525—15534
M-CSF secreted by gastric cancer cells exacerbates the progression of gastric cancer by increasing the expression of SHP2 in tumor-associated macrophages
Figure 8. M-CSF secreted by gastric cancer cells promotes SHP2 in TAM to increase the secretion of exosomes, and also promotes the secretion of MMPs and Arginase-1 through the Src/PI3K/AKT axis, thereby promoting the M2 polarization and migration and invasion ability of TAM.