Research Paper Volume 16, Issue 3 pp 2161—2180
Integrative analysis of LAG3 immune signature and identification of a LAG3-related genes prognostic signature in kidney renal clear cell carcinoma
Figure 4. Association between LAG3 expression and cancer immunity cycle (steps 1–7) in KIRC. Association between LAG3 expression and cancer-immunity cycle (steps 1–7) in KIRC. Cancer-immunity cycle including release of cancer cell antigens (Step 1), cancer antigen presentation (Step 2), priming and activation (Step 3), trafficking of immune cells to tumors (Step 4), infiltration of immune cells into tumors (Step 5), recognition of cancer cells by T cells (Step 6) and killing of cancer cells (Step 7). The above 7-step immune activity scores were calculated for each sample of the KIRC dataset based on single-sample gene set enrichment analysis to assess the correlation between LAG3 expression and anti-cancer immune status.